Fashion, design and Leonardo's Last Supper
Milan is Italy at its most polished: a working city of fashion houses, design studios and trams, built around the spiky marble Duomo. Climb onto the cathedral roof among the spires, walk through the glass-roofed Galleria Vittorio Emanuele II and book well ahead to see Leonardo's Last Supper in Santa Maria delle Grazie. Evenings start with aperitivo along the Navigli canals, and the city makes an easy base for Lake Como and the Alps.